Multi-phasic pharmaceutical formulations of poorly...

A - Human Necessities – 61 – K

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Details

A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2675766

Pharmaceutical formulations are disclosed comprising a multi-phasic pharmaceutical composition comprising an active pharmaceutical ingredient, wherein the active pharmaceutical ingredient is in a particulate state, a solubilized state, or in both a particulate state and in a solubilized state; a solvent; a non-miscible liquid; a stabilizer; and water; wherein the pharmaceutical formulation is an oral dosage form. Such pharmaceutical formulations are capable of reducing the fed/fast variability and improving oral bioavailability to which a number of active pharmaceutical ingredients are susceptible. The pharmaceutical formulations of the invention, therefore are bioequivalent in fed and fasted states and improved oral bioavailability.

Cette invention concerne des formulations pharmaceutiques comprenant une composition pharmaceutique à phases multiples comprenant un composant pharmaceutique actif, où le composant pharmaceutique actif est dans un état particulaire, un état solubilisé ou à la fois dans un état particulaire et dans un état solubilisé ; un solvant ; un liquide non miscible ; un stabilisant ; et de l'eau ; où la formulation pharmaceutique est sous une forme galénique orale. De telles formulations pharmaceutiques sont capables de réduire la variabilité nourri/à jeun et d'améliorer la biodisponibilité orale auxquelles un certain nombre de composants pharmaceutiques actifs sont sensibles. Les formulations pharmaceutiques de l'invention sont donc bio-équivalentes dans les états nourri et à jeun et présentent une amélioration de la biodisponibilité orale.

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