C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4523 (2006.01) A61K 31/55 (2006.01) A61P 35/00 (2006.01) C07D 211/46 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2685029
Chemical agents, such as derivatives of hydroxy benzene moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
La présente invention concerne des agents chimiques, tels que des dérivés de groupes hydroxybenzène et des structures cycliques hétérocycliques similaires, dont leurs sels, agissant en tant qu'agents anticancéreux et antitumoraux, surtout lorsque lesdits agents modulent l'activité d'enzymes et de polypeptides structurels présents dans des cellules, par exemple des cellules cancéreuses, ou lorsque les agents modulent les niveaux d'expression génique dans des systèmes cellulaires, dont des cellules cancéreuses. L'invention concerne également des procédés de préparation desdits agents, ainsi que des compositions pharmaceutiques contenant lesdits agents en tant qu'ingrédients actifs et des procédés d'utilisation de ceux-ci en tant qu'agents thérapeutiques.
Chellappan Sheela
Ohler Norman E.
Strovel Jeffrey
Watthey Jeffrey W.
Avalon Pharmaceuticals
Smart & Biggar
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