Multi-site metal chelating agents

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 5/00 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 51/00 (2006.01) C07C 237/06 (2006.01) C07C 237/08 (2006.01) C07C 237/10 (2006.01) C07D 241/08 (2006.01) C07D 257/02 (2006.01) C07D 295/16 (2006.01) C07D 295/185 (2006.01) C07F 3/00 (2006.01) C07F 3/04 (2006.01) C07F 5/02 (2006.01) C07F 7/00 (2006.01) C07F 9/00 (2006.01) C07F 9/50 (2006.01) C07F 11/00 (2006.01) C07F 15/00 (2006.01) C07K 2/00 (2006.01) A61K 49/02 (1990.01)

Patent

CA 2069886

2069886 9105762 PCTABS00005 There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.

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