Multi-stage cascase boosting vaccine

Details Multi-stage cascase boosting vaccine Multi-stage cascase boosting vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 35/14 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 15/13 (2006.01) C12N 15/16 (2006.01)

Patent

CA 2194166

Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti- idiotype antibodies that mimic an epitope of antigen that is associated with a tumor or infectious agent. Antibodies and cytokines also may be used to amplify the immune cascade. Moreover, antibodies and anti-idiotype antibodies can be used to produce T cells that are not MHC-restricted and that are targeted to tumor cells and infectious agents.

Des réponses immunitaires humorales et cellulaires vis-à-vis de cellules tumorales et d'agents infectieux sont induites chez un mammifère au moyen d'un vaccin comprenant des anticorps et des anticorps anti-idiotype qui imitent un épitope d'un antigène associé à une tumeur ou à un agent infectieux. On peut également utiliser des anticorps et des cytokines pour amplifier les réponses immunitaires en cascade. On peut en outre utiliser des anticorps et des anticorps anti-idiotypes pour produire des lymphocites T qui ne sont pas CMH-restreints et qui sont dirigés contre des cellules tumorales et des agents infectieux.

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