G - Physics – 01 – N
Patent
G - Physics
01
N
150/13
G01N 1/28 (2006.01) C12Q 1/02 (2006.01) G01N 1/36 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/04 (2006.01)
Patent
CA 1295218
MULTI-TUMOR (SAUSAGE) TISSUE SLICES AND METHODS OF PRODUCING SUCH SLICES AND OF TESTING THE TISSUES IN SUCH SLICES Abstract of the Disclosure A plurality of tissue rods have a relatively great length (e.g., 10 mm) and a relatively small cross-sectional area (e.g., 1 mm2) in a transverse, preferably perpendicular, plane. The rods may constitute (1) an array of well characterized neoplasms of varying histogenesis and degrees of differentiation and a spectrum of normal tissues, (2) groups of tissues with related types of tumors and/or normal tissues, (3) tissue groups of defined classes and/or tissue groups as control samples and/or (4) representative tissue samples from defined patient populations. The rods are disposed in substantially parallel relationship in a casing having suitable dimensions (e.g., 2 cm x 3 cm). The casing may be formed from a suitable material such as portions of small intestines of small animals such as rabbits and may be stretched, preserved and stored. The casing may be tightly wrapped around the rods and bound as by a fine thread. The ends of the rods and the casing may be trimmed to insure that the rod ends are exposed. When the rods are disposed in groups in the casing, septums in the casing may separate the different groups. The thread is removed and the combination is embedded as in paraffin. The paraffin block is then sectioned to produce one thousand (1000) or more substantially identical slides. A single drop of a suitable material such as a hybridoma supernatant which may contain a monoclonal antibody may then be applied to individual ones of the slides to immuno react with the sectioned rods in the slides. The staining intensity of each rod section indicates the relative amount of the immuno reaction between the hybridoma supernatant and such rod section.
529387
Beckman Research Institute Of The City Of Hope
Sim & Mcburney
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