A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/21 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07C 69/74 (2006.01) C07C 203/04 (2006.01) C07C 233/36 (2006.01) C07C 235/44 (2006.01) C07C 271/20 (2006.01) C07C 321/04 (2006.01) C07C 323/12 (2006.01) C07D 207/333 (2006.01) C07D 211/58 (2006.01) C07D 215/56 (2006.01) C07D 233/90 (2006.01) C07D 235/30 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14
Patent
CA 2320290
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment of inflammation, pain, fever and the like.
L'invention concerne des composés à liaisons multiples inhibant cyclooxygénase-2 (COX-2), une enzyme qui catalyse la première phase déterminée dans la biosynthèse de prostaglandines. Les composés à liaisons multiples de la présente invention contiennent 2 à 10 ligands à liaison covalente avec une ou plusieurs séquences de liaison. Chaque ligand est une fraction capable de se lier à COX-2. Les composés à liaisons multiples de la présente invention s'utilisent pour le traitement d'inflammations, de douleurs, de fièvre et analogues.
Griffin John H.
Higgins Deborah L.
Judice J. Kevin
Advanced Medicine Inc.
Griffin John H.
Higgins Deborah L.
Judice J. Kevin
Torys Llp
LandOfFree
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