Multiclass hybrid interferons

Details Multiclass hybrid interferons Multiclass hybrid interferons

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/00 (2006.01) C07K 14/555 (2006.01) C07K 14/565 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1210715

-44- MULTICLASS HYBRID INTERFERONS Abstract New multiclass hybrid interferon polypep- tides, their corresponding encoding recombinant DNA molecules and transformed hosts which produce the new interferons are described. The amino acid sequences of these hybrids include at least two different subse- quences, one of which has substantial homology with a portion of a first class of interferon (eg, HuIFN-.alpha.) and the other which has substantial homology with a portion of a second class of interferon (eg, HuIFN-.beta.). Data indicates the interferon activity of a-.beta. hybrids may be substantially restricted to either cell growth regulatory activity or antiviral activity.

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