Multicyclic bis-amide mmp inhibitors

Details Multicyclic bis-amide mmp inhibitors Multicyclic bis-amide mmp inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 19/00 (2006.01) C07D 239/34 (2006.01) C07D 239/42 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2589328

The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP- 13 inhibitors. Formula (I).

La présente invention concerne d~une façon générale le groupe bis-amide contenant des agents pharmaceutiques, et notamment, les composés inhibiteurs des MMP-13 de bis-amide multicyclique. Plus particulièrement, la présente invention fournit une nouvelle classe de composés inhibiteurs des MMP-13, contenant un groupe bis-amide pyrimidinyle en association avec une fraction hétérocyclique, qui présente une activité et une solubilité soutenue par rapport au groupe bis-amide actuellement connu contenant les inhibiteurs des MMP-13. Formule (I).

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