Multicyclic compounds which inhibit leukocyte adhesion...

Details Multicyclic compounds which inhibit leukocyte adhesion... Multicyclic compounds which inhibit leukocyte adhesion...

C - Chemistry, Metallurgy

07

C

C07C 233/63 (2006.01) A61K 31/16 (2006.01) C07C 237/22 (2006.01) C07C 255/60 (2006.01) C07C 271/22 (2006.01) C07C 271/42 (2006.01) C07C 275/16 (2006.01) C07C 275/20 (2006.01) C07D 213/55 (2006.01) C07D 213/64 (2006.01) C07D 213/80 (2006.01) C07D 213/89 (2006.01) C07D 239/52 (2006.01) C07D 239/54 (2006.01) C07D 261/08 (2006.01) C07D 277/48 (2006.01) C07D 295/15 (2006.01) C07D 295/205 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2357781

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

Cette invention concerne des composés se liant à VLA-4. Certains de ces composés se caractérisent également par une adhésion leucocytaire, en particulier par une adhésion leucocytaire provoquée par VLA-4. Ces composés conviennent pour le traitement de maladies inflammatoires chez des mammifères, l'homme notamment, telles qu'asthme, maladie d'Alzheimer, athérosclérose, syndrome démentiel du SIDA, diabète, maladie intestinale inflammatoire, polyarthrite rhumatoïde, transplantations tissulaires, métastases tumorales et ischémie myocardique. Ces composés peuvent également être administrés pour le traitement de maladies inflammatoires du cerveau telles que la sclérose en plaques.

Affiliated with

Also associated with

Rating

Multicyclic compounds which inhibit leukocyte adhesion... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multicyclic compounds which inhibit leukocyte adhesion..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multicyclic compounds which inhibit leukocyte adhesion... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2004209