C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/4427 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2615574
Disclosed herein are sulfonamide compounds of Formula (VII) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
La présente invention concerne les composés de sulfonamide de la Formule (VII) tels que décrits ici. Des procédés et des compositions sont dévoilés pour le traitement d~états de maladie incluant, mais sans s~y limiter, les cancers, les maladies auto-immunes, les détériorations de tissus, les troubles du système nerveux central, les troubles à neurodégénérescence, la fibrose, les troubles osseux, les troubles liés à la répétition de polyglutamine, les anémies, les thalassémies, les maladies inflammatoires, les maladies cardiovasculaires et les troubles dans lesquels l~angiogénèse joue un rôle dans la pathogénèse, en utilisant les composés de l~invention. Par ailleurs, les procédés de modulation de l~activité de l~histone déacétylase (HDAC) sont également dévoilés.
Bonnefous Celine
Hager Jeffrey H.
Hassig Christian A.
Hoffman Timothy Z.
Malecha James W.
Bonnefous Celine
Hager Jeffrey H.
Hassig Christian A.
Hoffman Timothy Z.
Kalypsys Inc.
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