Multicyclic tertiary amine polyaromatic squalene synthetase...

Details Multicyclic tertiary amine polyaromatic squalene synthetase... Multicyclic tertiary amine polyaromatic squalene synthetase...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) C07D 233/56 (2006.01) C07D 239/06 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 471/18 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2105655

2105655 9215579 PCTABScor01 This invention relates to polycyclic compounds containing two mono and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

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