Multidrug resistance inhibitors

Details Multidrug resistance inhibitors Multidrug resistance inhibitors

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2193578

There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: (see fig. I) (I) wherein n is an integer of 5 to 12, R1 and R2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from hydroxy, (C1-C4)alkyl, (C1-C4)alkoxy and halogen, and/or by methylenedioxy, with the proviso that R1 and R2 are simultaneously not a compound of formula (II). (see fig. II) (II)

Inhibiteur de résistance multiple aux médicaments pour surmonter une multirésistance aux anti-cancéreux, ou agent qui stimule l'activité des agents anti-cancéreux, qui comprend comme ingrédient actif un composé de formule (I) ou un sel pharmaceutiquement acceptable de ce dernier : (voir fig. I) (I) où n est un nombre entier compris entre 5 et 12, R1 et R2 sont indépendamment l'un de l'autre un benzyle, dont un cycle phényle peut être substitué par 1 à 5 substituants choisis parmi un hydroxy, un alkyle en C1-C4, un alkoxy en C1-C4 et un halogène, et/ou par un groupe méthylènedioxy, à la condition que R1 et R2 ne soient pas en même temps un composé de la formule (II). (Voir fig. II) (II)

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