Multifunctional ligands for potential use in the design of...

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C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07F 9/535 (2006.01) C07F 9/94 (2006.01) C07F 13/00 (2006.01) A61K 49/02 (1990.01)

Patent

CA 2122726

2122726 9308839 PCTABS00021 A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, or a second phosphinimine moiety. These phosphinimine ligands are complexed to early transition metal radionuclides (e.g. 99mTc or 186Re/188Re) or late transition metals (e.g., 105Rh or 109Pd). The complexes with these metals 186Re/188Re, 99mTc and 109Pd exhibit a high in vitro and high in vivo stability. The complexes are formed in high yields and can be neutral or charged. These ligands can also be used to form stable compounds with paramagnetic transition metals (e.g. Fe and Mn) for potential use as MRI contrast agents. Applications for the use of ligands and making the ligands are also disclosed.

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