Multifunctional molecular complexes for gene transfer to cells

Details Multifunctional molecular complexes for gene transfer to cells Multifunctional molecular complexes for gene transfer to cells

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/11 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2201396

A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided. The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.

Complexe moléculaire multifonctionnel pour le transfert d'une composition d'acide nucléique sur une cellule cible. Le complexe est constitué de A) la composition d'acide nucléique et B) une fraction de transfert renfermant 1) une ou plusieurs polyamines cationiques liées à la composition d'acide nucléique précitée, 2) un ou plusieurs composants de rupture de membrane endosome attachés à au moins un élément azote de la polyamine et (3) un ou plusieurs composants de liaison spécifique du récepteur.

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