C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2469714
The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.
La présente invention concerne des anticorps monoclonaux protecteurs qui se fixent au peptidoglycane de bactéries Gram-positif. Lesdits anticorps se fixent également à ces bactéries, favorisant la phagocytose et la mort des bactéries in vitro et bloquant la colonisation nasale par les bactéries Gram-positifs in vivo. L'invention concerne également des anticorps humains, humanisés et chimériques. L'invention concerne en outre des régions variables de chaîne lourde et de chaîne légère d'un anticorps.
Fischer Gerald W.
Foster Simon
Kokai-Kun John F.
Schuman Richard F.
Stinson Jeffrey R.
Biosynexus Incorporated
Kirby Eades Gale Baker
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