C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2406993
The present invention relates to a multifunctional polypeptide comprising a first domain comprising a binding site specifically recognizing an extracellular epitope of the NKG2D receptor complex and a second domain having receptor or ligand function. Furthermore, the present invention relates to polynucleotides encoding the multifunctional polypeptide, to vectors comprising said polypeptides and to cells comprising said polynucleotides or said vectors. The invention also relates to compositions comprising either of the above recited molecules, alone or in combination, as well as to specific medical uses of the multifunctional polypeptide of the invention.
L'invention porte sur un polypeptide multifonnctionnel comportant un premier domaine comprenant un site de fixation reconnaissant spécifiquement un épitope du complexe récepteur NKG2D, et un deuxième domaine à fonction de récepteur ou de ligand. L'invention porte également sur des polynucléotides codant pour ledit polypeptide multifonctionnel, sur des vecteurs comprenant lesdits polypeptides, et sur des cellules comprenant lesdits polynucléotides ou lesdits vecteurs. L'invention porte en outre sur des compositions comprenant les molécules mentionnées ci-dessus, soit seules, soit en combinaison, et sur des utilisations médicales spécifiques du polypeptide multifonctionnel de l'invention.
Borschert Katrin
Hofmeister Robert
Kischel Roman
Kufer Peter
Lutterbuse Ralf
Goudreau Gage Dubuc
Micromet Ag
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