C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/55 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C12N 15/15 (2006.01)
Patent
CA 2430973
Fusion proteins of protease inhibitors are provided, in particular fusion proteins of alpha 1-antitrypsin (AAT) and a second protease inhibitor, such as secretory leukocyte protease inhibitor (SLPI) or tissue inhibitor of metalloproteases (TIMP). Polynucleotides encoding the fusion proteins, vectors comprising such polynucleotides, and host cells containing such vectors are also provided. Methods of making the fusion proteins of the invention are also provide, as well as methods of using the fusion proteins, for example to inhibit protease activity in a biological sample or in the treatment of an individual suffering from, or at risk for, a disease or disorder involving unwanted protease activity.
La présente invention concerne des protéines de fusion d'inhibiteurs de protéase, en particulier des protéines hybrides d'antitrypsine alpha 1(AAT) et un second inhibiteur de protéase, tel qu'un inhibiteur de protéases leucocytaires sécrétrices (SLPI) ou un inhibiteur tissulaire de métalloprotéases (TIMP). L'invention concerne également des polynucléotides codant les protéines hybrides, des vecteurs comprenant de tels polynucléotides, et des cellules hôtes contenant de tels vecteurs. L'invention concerne également des méthodes de fabrication de protéines hybrides, ainsi que des méthodes d'utilisation des protéines hybrides, par exemple de manière à inhiber l'activité protéasique dans un échantillon biologique ou dans le traitement d'un individu souffrant d'une maladie ou d'un trouble, ou susceptible de contracter une maladie ou un trouble affectant l'activité protéasique indésirée.
Barr Philip J.
Gibson Helen L.
Pemberton Philip
Arriva Pharmaceuticals Inc.
Borden Ladner Gervais Llp
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