C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/06 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2679943
The present invention concerns prognosis for glioblastoma and/or assessment of the response of an individual to therapy for glioblastoma treatment. In particular, expression analysis of two or more specific genes provided in the invention is determined to predict outcome for the individual and/or to predict if the individual will respond to therapy, such as chemoradiation, for example. In specific embodiments, a multigene set from a sample from the individual is compared to a reference set of housekeeping genes. fold-change
La présente invention porte sur le pronostic d'un glioblastome et/ou sur l'évaluation de la réaction d'un individu au traitement du glioblastome. À cet effet, on effectue notamment l'analyse de l'expression d'au moins deux gènes spécifiques, de l'invention, pour prédire les résultats de traitement de l'individu et/ou pour prédire comment l'individu réagira à une thérapie, telle que la chimioradiothérapie. Selon des modes de mise en oeuvre spécifiques, on compare un ensemble de plusieurs gènes d'un échantillon prélevé sur un individu à un ensemble de référence de gènes domestiques.
Aldape Kenneth
Colman Howard
Zhang Li
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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