Multilayer microfluidic probe head and method of fabrication...

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01) B01L 3/00 (2006.01) B01L 3/02 (2006.01)

Patent

CA 2755298

The invention is directed to a multilayer microfluidic probe (MFP) head (100). The head typically comprises a first (110) and second (120) layers facing each others, and at least one tubing port (182), extending from the first layer (110). The first layer comprises one or more via (112), whereby fluid communication is enabled through the first layer towards the second layer. The second layer comprises at least one microchannel (124), relaying fluid communication to an aperture (122). Such a multilayered MFP head is easier to fabricate than heads made with unitary construction. In particular, a microchannel can advantageously be engraved a groove (124) at the level of the interface between the two layers. The MFP head can further be interfaced with tubing using e.g. a standard fitting for tubing port. The invention has substantial potential for e.g. patterning continuous and discontinuous patterns of biomolecules on surfaces as well as for direct processing of resist materials in a non- contact mode.

L'invention porte sur une tête (100) de sonde microfluidique multicouche (MFP). La tête comprend typiquement une première couche (110) et une seconde couche (120) en regard l'une de l'autre, et au moins un orifice formant tube (182), s'étendant à partir de la première couche (110). La première couche comprend une ou plusieurs traversées (112), grâce auxquelles une communication fluidique est rendue possible à travers la première couche, vers la seconde couche. La seconde couche comprend au moins un microcanal (124), qui relaie la communication fluidique vers une ouverture (120). Une telle tête MFP multicouche est plus facile à fabriquer que les têtes réalisées selon une construction monobloc. En particulier, il est possible de graver avantageusement une rainure (124) dans un microcanal, au niveau de l'interface entre les deux couches. La tête MFP peut en outre être interfacée avec le tube par utilisation, par exemple, d'un raccord standard pour orifice formant tube. L'invention présente un fort potentiel, par exemple pour la réalisation de motifs continus et discontinus de biomolécules sur des surfaces, ainsi que pour le traitement direct de matériaux de réserve en mode sans contact.

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