A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2659523
This invention pertains to an orally disintegrating multilayer tablet characterized in that it comprises at least two discrete layers, one of which comprises at least one active agent that promotes the oxidation of opioids, preferably acetaminophen, and the other of which contains granules including an inert core which is coated with at least one opioid and at least one binder, wherein said opioid coating is coated with a subcoat comprising a compound soluble in gastric fluids, said subcoat being coated with a taste-masking coating comprising a polymer or copolymer comprising dialkylaminoalkyl (meth) acrylate units and optionally a pore-forming agent.
Cette invention concerne un comprimé multicouches se désintégrant par voie orale, caractérisé en ce qu'il comprend au moins deux couches discrètes, dont l'une comprend au moins un agent actif qui favorise l'oxydation des opioïdes, de préférence de l'acétaminophène, et dont l'autre contient des granulés comprenant un noyau inerte qui est enrobé d'au moins un opioïde et d'au moins un liant, ledit enrobage d'opioïde étant enrobé d'un sous-enrobage comprenant un composé soluble dans les fluides gastriques, ledit sous-enrobage étant enrobé d'un enrobage masquant le goût comprenant un polymère ou copolymère comprenant des unités de dialkylaminoalkyl(méth)acrylate et facultativement un agent formant des pores.
Herry Catherine
Hoarau Didier
Oury Pascal
Ethypharm
Robic
LandOfFree
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