Multilayered controlled-release oral solid pharmaceutical forms

Details Multilayered controlled-release oral solid pharmaceutical forms Multilayered controlled-release oral solid pharmaceutical forms

A - Human Necessities

61

K

A61K 9/24 (2006.01)

Patent

CA 2144167

Disclosed is a novel pharmaceutical form, consisting of a tablet capable of releasing the active material under controlled and differentiated rates; the novel pharmaceutical form is designed so as to obtain optimum plasmatic levels of the drug for a predeterminable period of time and thus making it possible to simplify the posological scheme, achieving at the same time a higher and certain therapeutic utilisation. Fundamentally, it is a two or more layered tablet, of which one at least intended to release a drug portion in short times, a second layer and optionally a third layer being suitable for gradually releasing portions of active principle.

L'invention concerne une forme pharmaceutique nouvelle, qui est un compriné permettant la libération du composé actif à des vitesses contrôlées et différentiées; cette forme pharmaceutique nouvelle est conçue pour assurer des niveaux plasmiques optimaux du médicament pendant une durée de temps prédéterminée, ce qui permet de simplifier le schéma posologique et, par la même occasion, d'assurer une thérapie améliorée et plus sûre. Plus précisément, c'est un comprimé en deux couches ou plus, dont une au moins est conçue pour libérer une partie du médicament sur une courte durée de temps. La seconde couche et, éventuellement, une troisième couche permettent une libération graduelle du principe actif, par portions.

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