Multilayered controlled release pharmaceutical dosage form

Details Multilayered controlled release pharmaceutical dosage form Multilayered controlled release pharmaceutical dosage form

A - Human Necessities

61

K

A61K 9/54 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2185893

This invention is directed to a multilayered controlled release pharmaceutical dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particles wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate release to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the multilayered coated particle.

L'invention concerne une forme galénique pharmaceutique multicouche à libération contrôlée, en particulier une forme galénique adaptée aux médicaments hydrosolubles. Cette forme galénique comprend une pluralité de particules enrobées dont chacune présente des couches multiples autour d'un noyau renfermant un principe actif. Le noyau renfermant le principe actif et au moins une autre couche de principe actif sont enrobés d'une couche barrière à libération contrôlée. De préférence, une couche extérieure de principe actif supplémentaire est conçue pour une libération immédiate afin de fournir de préférence une couche à libération immédiate et au moins deux couches à libération contrôlée d'un principe actif hydrosoluble à partir d'une particule multicouche enrobée.

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