Multimeric complexes of antigens and an adjuvant

Details Multimeric complexes of antigens and an adjuvant Multimeric complexes of antigens and an adjuvant

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) C07K 14/00 (2006.01) C07K 14/445 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2631039

The invention relates to a product which comprises a C4bp domain of a non- mammalian origin, particularly SEQ ID NO:1, SEQ ID NO:23 or SEQ ID NO:37, or a variant thereof, and an antigen. The product is desirably in the form of a fusion protein. The chicken C4bp domain of SEQ ID NO:1 and SEQ ID NO:23 is also described. Antigens include monomeric antigens such as malarial and influenza antigens. The C4bp domain provides for assembly of multimeric complexes of the antigen, or mixtures thereof. The complexes are useful as vaccines.

L'invention concerne un produit comprenant un domaine C4bp d'origine non mammifère, et notamment SEQ ID NO:1, SEQ ID NO:23 ou SEQ ID NO:37, ou un variant correspondant, et un antigène. Le produit se présente de préférence sous la forme d'une protéine hybride. L'invention concerne également le domaine C4bp aviaire de SEQ ID NO:1 et SEQ ID NO:23. Les antigènes comprennent des antigènes monomères tels que des antigènes paludéens et grippaux. Le domaine C4bp permet l'assemblage de complexes multimères de l'antigène, ou de mélanges correspondants. Ces complexes sont utiles comme vaccins.

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