Multimeric conjugate

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 65/333 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2677041

The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.

La présente invention concerne un agent multimère et un conjugué multimère formé à partir de cet agent multimère et d'un agent biologiquement actif. Lesdits conjugués multimères ont une longue durée de vie in vivo et une avidité accrue par rapport à l'agent biologique non modifié. La présente invention concerne en outre une composition pharmaceutique ou de diagnostic contenant ledit conjugué ainsi que son procédé de fabrication. L'invention concerne de plus l'utilisation desdits conjugués pour la détection, la détermination, la séparation et/ou l'isolement d'un partenaire de liaison spécifique et pour le diagnostic, la prophylaxie et le traitement de maladies dans lesquelles le partenaire de liaison spécifique est directement ou indirectement mis en jeu.

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