Multimeric erythropoietin with increased biological activity

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/505 (2006.01) A61K 38/16 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2272603

Modified polypeptides with increased biological activity exhibited as either increased potency or prolonged circulating half-life are disclosed with methods of preparing the modified polypeptides and methods of use.

On décrit des polypeptides modifiés possédant une activité biologique accrue, se manifestant soit par une efficacité accrue, soit par une demi-durée de vie prolongée dans le système circulatoire. On décrit, également, des procédés pour préparer ces polypeptides modifiés et des méthodes d'utilisation.

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