Multimeric forms of human rhinovirus receptor protein

Details Multimeric forms of human rhinovirus receptor protein Multimeric forms of human rhinovirus receptor protein

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2116109

2116109 9400485 PCTABS00030 The present invention relates to novel forms and configurations of intercellular adhesion molecule (ICAM) including multimeric configurations that effectively bind to human rhinovirus and can effectively reduce HRV infectivity. When in a multimeric configuration, preferably as dimers, these proteins display enhanced binding of HRV and are able to reduce HRV infectivity as well as the infectivity of other viruses known to bind to the "major" group human rhinovirus receptor (HRR). The multimerized proteins may also be used to block tICAM interaction with lymphocyte function-associated antigen-1 (LFA-1).

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