Multimeric forms of members of the steroid/thyroid...

Details Multimeric forms of members of the steroid/thyroid... Multimeric forms of members of the steroid/thyroid...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2121800

2121800 9311235 PCTABS00022 In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first receptor species with a second receptor species modulates the ability of the first receptor species to trans-activate transcription of genes maintained under hormone expression control in the presence of the cognate ligand for said first receptor.

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