Multimeric polyvalent antithrombotic agents

Details Multimeric polyvalent antithrombotic agents Multimeric polyvalent antithrombotic agents

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 7/02 (2006.01) C07D 207/452 (2006.01) C07K 7/06 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145847

This invention relates to antithrombotic agents and uses thereof. Specifically, the invention relates to chemical moieties that specifically bind to platelets and inhibit their aggregation, including linear and cyclic peptides. The invention provides meth- ods for using these antithrombotic agents to prevent the formation of thrombi at sites in a mammalian body. In particular, the platelet-specific binding moieties including linear and cyclic peptides of the invention are covalently linked to a polyvalent linker moiety, so that the polyvalent linker moiety is covalently linked to a multiplicity of the platelet-specific binding moieties including linear and cyclic peptides. Efficacious antithrombotic agents are thereby provided.

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