Multimeric, recombinant urease vaccine

A - Human Necessities – 61 – K

Patent

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A61K 39/106 (2006.01) A61K 39/39 (2006.01) C12N 9/80 (2006.01)

Patent

CA 2219201

Methods and compositions are provided for preventing and/or treating Helicobacter (e.g., H. pylori) infection. The compositions of the invention, which are used in the methods of the invention (which include mucosal administration of the compositions), include compositions containing multimeric complexes of recombinant, enzymatically inactive Helicobacter urease in a pharmaceutically acceptable carrier or diluent; and compositions containing (a) a Helicobacter antigen, and (b) an antibiotic, an antisecretory agent, a bismuth salt, or a combination thereof.

Cette invention concerne des procédés et des compositions qui permettent de prévenir et/ou de traiter les infections dues à l'Hélicobacter (par exemple, l'Hélicobacter pylori). Les compositions décrites dans l'invention, qui servent aux procédés décrits dans l'invention (qui incluent l'administration muqueuse de ces compositions), incluent des compositions contenant des complexes multimères d'uréase d'Hélicobacter recombinante, enzymatiquement inactive, dans un excipient ou un diluant pharmaceutiquement acceptable, ainsi que des compositions contenant (a) un antigène d'Hélicobacter et (b) un antibiotique, un agent antisécrétoire, un sel de bismuth ou une combinaison de ceux-ci.

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