Multiparticulate oral dosage forms

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/50 (2006.01) A61K 9/00 (2006.01) A61K 31/4184 (2006.01) A61K 31/4439 (2006.01) A61K 31/7048 (2006.01) A61K 47/48 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2355829

A convenient oral dosage form that contains a drug that is reversibly adsorbed to an ion-exchange resin and subsequently coated with a polymeric material is provided. Compositions of the invention are particularly advantageous for formulating acid labile drug compounds and/or drug compounds that have particularly strong and unpleasant tastes or odours. Methods of manufacturing the convenient oral dosage forms and final dosage forms that include the convenient oral dosage forms are also provided.

La présente invention concerne une forme posologique orale commode contenant un médicament absorbé de façon réversible sur une résine d'échanges d'ions puis enrobée d'une matière polymère. Les compositions de l'invention conviennent particulièrement à la formulation de composés médicamenteux instables en milieu acide et/ou de composés médicamenteux au goût prononcé voire désagréable. L'invention concerne également, d'une part des procédés de fabrication de telles formes posologiques orales commodes, et d'autre part des formes posologiques finales incluant ces formes posologiques orales commodes.

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