Multiparticulate pharmaceutical form comprising...

Details Multiparticulate pharmaceutical form comprising... Multiparticulate pharmaceutical form comprising...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/7088 (2006.01)

Patent

CA 2586597

The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 µm which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.

L'invention concerne une forme galénique orale multiparticulaire renfermant des pastilles qui ont une taille comprise entre 50 et 2500 ?m et qui sont pratiquement composées a) d'une couche matricielle interne contenant des nanoparticules qui renferment un principe actif acide nucléique et qui sont incorporées dans une matrice en polymère à action mucoadhésive, ainsi que b) d'un enrobage pelliculaire externe constitué pratiquement d'un polymère ou d'un copolymère anionique qui peut éventuellement être formulé avec des excipients pharmaceutiques courants, notamment des plastifiants.

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