Multiphoton excitation through optical fibers for...

A - Human Necessities – 61 – B

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A61B 6/00 (2006.01) A61B 5/00 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2398029

The present invention is directed to a method of applying radiation through an optical fiber (106) for detecting disease within a plant or animal or imaging a particular tissue of a plant or animal. In addition, fluorescence can be detected and localized within a subject by such application of radiation through an optical fiber (106). The radiation is effective to promote simultaneous multiphoton excitation. The optical fibers are used alone to examine internal regions of tissue, in conjunction with an optical biopsy needle (114) to evaluate sub-surface tissue, or with an endoscope (16) to evaluate tissue within the body cavities.

La présente invention concerne un procédé consistant à appliquer un rayonnement au moyen d'une fibre optique afin de détecter une maladie chez une plante ou un animal ou d'obtenir une image d'un tissu végétal ou animal particulier. En outre, l'application d'un rayonnement par une fibre optique permet de détecter et de localiser une fluorescence chez un sujet. Le rayonnement sert à favoriser l'excitation multiphotonique simultanée. Les fibres optiques sont utilisées soit seules pour l'examen de régions tissulaires internes, soit en association avec une aiguille de biopsie optique pour l'évaluation de tissus internes, soit avec un endoscope pour l'évaluation de tissus situés à l'intérieur de cavités corporelles.

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