Multiple agent therapy for sexual dysfunction

Details Multiple agent therapy for sexual dysfunction Multiple agent therapy for sexual dysfunction

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61K 31/00 (2006.01) A61K 49/00 (2006.01) C07K 7/00 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2568218

Multiple agent therapy for treatment of sexual dysfunction, including male erectile dysfunction, with sequential administration a type V phosphodiesterase inhibitor (PDE-5), such as sildenafil, preferably wherein the PDE-5 inhibitor is administered by oral dose means, and a melanocortin 3 and/or 4 receptor agonist, such as Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH (PT-141) preferably wherein the PT-141 is formulated for and administered by intranasal means, and further preferably wherein the PDE-5 inhibitor is administered prior to PT-141.

L'invention concerne une thérapie à agents multiples pour le traitement de dysfonctionnement sexuel, y compris les troubles de l'érection, par administration d'inhibiteur de phosphodiestérase de type 5 (PDE-5), du type sildénafil, de préférence par voie orale, et d'agoniste vis-à-vis des récepteurs de mélanocortine 3 et/ou 4, du type Ac-Nle-<i>cyclo</i>(-Asp-His-D-Phe-Arg-Trp-Lys)-OH (PT-141), et sachant de préférence que le PT-141 est formulé pour une administration intranasale, et de préférence encore que l'inhibiteur de PDE-5 est administré avant le PT-141.

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