C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/02 (2006.01) C12N 1/19 (2006.01)
Patent
CA 2067590
43/JWW24 18350 TITLE OF THE INVENTION MULTIPLE HEPATITIS B VIRUS SURFACE PROTEINS WHICH FORM PARTICLES ABSTRACT OF THE INVENTION In order to produce a mixture hepatitis B virus (HBV) surface proteins in the form of particles, DNA encoding two or more HBV proteins was expressed by a single recombinant yeast. In order to form particles with substantially reduced carbohydrate, such DNA encoding two or more HBV proteins is expressed in a single recombinant yeast host which is deficient in its ability to glycosylate proteins. These B V proteins display the antigenic sites genetically encoded by the S domain (including the preS domain) of the HBV virion envelope open reading frame and 43/JWW24 - i - 18350 when expressed in a yeast deficient for its ability to glycosylate, contain substantially reduced levels of entrapped carbohydrate when compared with HBsAg particles produced in yeast cells "wild-type" for glycosylation. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV including antigenic variants in the immunodominant epitopes of the surface protein and also are useful as antigens and immunogens for development of diagnostic tests for such diseases or infections.
Burke Pamela
Hagopian Arpi
Kniskern Peter J.
Short Kathryn R.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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