Multiple sample introduction mass spectrometry

H - Electricity – 01 – J

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H01J 49/26 (2006.01) H01J 49/04 (2006.01)

Patent

CA 2299439

A multiple sample introduction mass spectrometer apparatus (1) having atmospheric pressure ion sources (3, 4, 6, 7) interfaced to mass analyzers (21) for introducing samples through multiple electrospray (ES) and atmospheric pressure chemical ionization (APCI) probes (3, 4, 6, 7). The mass spectra containing internal calibration peaks can be achieved by spraying different solutions simultaneously from the multiple inlet probes (3, 4, 6, 7). The electrospray (ES) and atmospheric pressure chemical ionization (APCI) probes (3, 4, 6, 7) are arranged in one atmospheric pressure ionization chamber (20) and can be switched on or off during an analytical run.

L'invention concerne un dispositif (1) de spectrométrie de masse avec introduction d'échantillons multiples. Ce dispositif comprend des sources (3, 4, 6, 7) d'ions de pression atmosphérique connectées à des analyseurs (21) de masse, ces sources permettant d'introduire les échantillons à travers des sondes (3, 4, 6, 7) multiples d'électrovaporisation (ES: electrospray) et d'ionisation chimique à pression atmosphérique (APCI: atmospheric pressure chemical ionization). Le spectre de masse contenant des pics d'étalonnage internes peut être réalisé par la vaporisation simultanée de différentes solutions à partir des sondes (3, 4, 6, 7) d'entrée multiples. Les sondes d'électrovaporisation (ES) et d'ionisation chimique à pression atmosphérique (APCI) sont disposées dans une chambre (20) d'ionisation unique et peuvent être commutées en position "marche" ou "arrêt" au cours d'un cycle d'analyse.

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