Multiple sclerosis t-cell receptor

Details Multiple sclerosis t-cell receptor Multiple sclerosis t-cell receptor

C - Chemistry, Metallurgy

07

K

C07K 14/725 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 25/28 (2006.01) C07K 7/08 (2006.01) C12Q 1/68 (2006.01) A61K 38/11 (2006.01) A61K 38/08 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07K 7/06 (2006.01) C12N 5/08 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2078549

This invention is directed to therapeutic agents comprising peptides in turn comprising a portion of the T-cell manifested in multiple sclerosis. Embodiments of the invention include peptides, vaccines, receptors and entire (attenuated) T-cells. This invention is also directed to methods using the foregoing agents to suppress immune response against myelin basic protein, and/or to suppress T-cells that recognize an immunodominant epitope of human myelin basic protein. Additionally, this invention is directed to diagnostic methods and kits for diagnosing multiple sclerosis.

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