Multiple sclerosis therapy and diagnosis

Details Multiple sclerosis therapy and diagnosis Multiple sclerosis therapy and diagnosis

A - Human Necessities

61

K

A61K 31/704 (2006.01) A61K 31/407 (2006.01) A61K 31/58 (2006.01) A61K 31/70 (2006.01) A61P 25/28 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2613210

Use of a compound capable of reducing the activity of Core 2 GlcNAc-T in the manufacture of a medicament for the treatment of Multiple Sclerosis is disclosed. Also disclosed is a method of diagnosing Multiple Sclerosis in a subject and a method of determining the utility of a test substance for use in the treatment of Multiple Sclerosis comprising determining the ability of the substance to inhibit the activity of Core 2 GlcNAc-T.

L'invention concerne l'utilisation d'un composé capable de réduire l'activité de noyau 2 GlcNAc-T dans la fabrication d'un médicament destiné au traitement de la sclérose en plaques. L'invention concerne également un procédé de diagnostic de la sclérose en plaques chez un sujet et un procédé permettant de déterminer l'utilité d'une substance de test à utiliser dans le traitement de la sclérose en plaques et consistant à déterminer la capacité de la substance à inhiber l'activité de noyau 2 GlcNAc-T.

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