Multiple step entrapment/loading procedure for preparing...

Details Multiple step entrapment/loading procedure for preparing... Multiple step entrapment/loading procedure for preparing...

A - Human Necessities

61

K

167/163, 167/182

A61K 9/127 (2006.01) A61K 31/65 (2006.01)

Patent

CA 1331860

ABSTRACT Novel liposome-entrapped cationic, lipophilic drug composition-, e.g., anthracycline antineoplastic agent compositions, and multistep entrapment/loading procedures for preparing them are disclosed. These procedures involve forming liposomes from phospholipids, such as distearoyl phosphatidyl- choline or a similar long chain fatty acid diester phospholipid, to be loaded with the drug, e.g., daunorubicin or doxorubicin, in aqueous medium in the presence of an acid, e.g., an organic acid which can be a monofunctional pyranosidyl acid such as lactobionic acid, adding the drug, and then adding a base such as calcium carbonate whose cations cannot pass through the vesicles' bilayers to charge neutralize the organic acid anions in the external aqueous phase and induce the acid anions in the internal aqueous phase to become charge neutralized by attracting the cationic, lipophilic drug.

583476

Affiliated with

Also associated with

Rating

Multiple step entrapment/loading procedure for preparing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Multiple step entrapment/loading procedure for preparing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Multiple step entrapment/loading procedure for preparing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1289555