Multiple unit pharmaceutical formulation

Details Multiple unit pharmaceutical formulation Multiple unit pharmaceutical formulation

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2654402

An orally disintegratable benzimidazole formulation, featuring a plurality of compressed pellets in a MUPS tablet. The individual units feature a substrate with the active ingredient and an enteric coating, optionally with a subcoating between the substrate and the enteric coating. The individual units are preferably at least partially coated with an outer coating which features a stress absorber, thereby enabling the pellets to be compressed without disturbing the integrity of the enteric coating. The enteric coating preferably does not feature a plasticizer.

L'invention concerne une formulation de benzimidazole orodispersible comprenant plusieurs granules dans un comprimé MUPS. Les unités individuelles comprennent un substrat qui comporte le principe actif ainsi qu'un enrobage entérosoluble, un sous-enrobage pouvant éventuellement être appliqué entre le substrat et l'enrobage entérosoluble. De préférence, les unités individuelles sont au moins partiellement revêtues d'un enrobage externe qui absorbe les contraintes, ce qui permet de comprimer les granules sans modifier l'intégrité de l'enrobage entérosoluble. De préférence, cet enrobage entérosoluble ne comprend aucun plastifiant.

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