A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 17/06 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2504868
Multiple-variable dose methods for treating TNF.alpha.-related disorders, including Crohn's disease and psoriasis, comprising administering TNF.alpha. inhibitors, including TNF.alpha. antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.
L'invention concerne des méthodes utilisant un régime posologique à variables multiples pour traiter des troubles associés à TNF?, y compris la maladie de Crohn et le psoriasis. Ces méthodes consistent à administrer des inhibiteurs de TNF?, dont des anticorps de TNF?. Elles consistent également à administrer d'abord un inhibiteur de TNF lors d'une phase d'induction ou de charge, ensuite de l'agent lors d'une phase d'entretien ou de traitement, l'inhibiteur de TNF étant administré en doses plus fortes lors de la phase d'induction.
Chartash Elliot Keith
Granneman George Richard
Hoffman Rebecca S.
Taylor Lori K.
Yan Philip
Abbott Biotechnology Ltd.
Torys Llp
LandOfFree
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