Multiplex assays for inferring ancestry

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2598455

Oligonucleotide primers and probes for detecting Ancestry informative marker (AIMs) polynucleotides that contain a single nucleotide polymorphism or that contain an insertion or deletion, are provided, as are methods of using the oligonucleotide primers and probes to draw an inference as to a trait of an individual. The trait can be, for example, biogeographical ancestry, a pigmentation trait, responsiveness to a drug, or susceptibility to a disease. Also provided are methods of determining the proportional ancestry of an individual. Reagents and kits also are provided.

L'invention concerne des amorces et des sondes oligonucléotidiques permettant de détecter des polynuclétotides marqueurs informatifs d'ascendance (AIM) qui contiennent un polymorphisme mononucléotidique ou qui contiennent une insertion ou une délétion, ainsi que des procédés d'utilisation des amorces et sondes oligonuclétotidiques pour tirer une inférence constituant un trait d'un individu. Le trait peut être, par exemple, l'ascendance biogéographique, un trait de pigmentation, une réactivité à un médicament ou une sensibilité à une maladie. L'invention concerne également des procédés de détermination de l'ascendance proportionnelle d'un individu. L'invention concerne également des réactifs et des kits.

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