C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) A61K 35/34 (2006.01) A61L 27/24 (2006.01) C12N 5/10 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2402245
Described are conduction cardiomyocyte-enriched cellular populations, and methods and materials for obtaining the same. The populations may be used to engraft mammalian myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial tissue, for example to provide biological pacemakers. Also described are restorative cellular myocardial grafts for improving the contractile function of injured segments of myocardium, and articles adapted for heart implantation (e.g. conductive pacemaker leads), which includes coatings of viable cardiomyocytes and optionally a carrier for the cardiomyocytes.
L'invention concerne des populations cellulaires enrichies en cardiomyocytes de conduction, ainsi que des procédés et des matériaux nécessaires à leur obtention. Ces populations peuvent être utilisées pour faire prendre une greffe de tissu myocardique mammalien, par exemple dans la mise en place de stimulateur cardiaque biologique. L'invention concerne aussi des greffes myocardiques cellulaires restauratrices destinées à améliorer la fonction contractile de segments du myocarde endommagés, ainsi que des articles conçus pour être implantés dans le coeur (par exemple des électrodes de stimulateur cardiaque), recouverts de cardiomyocytes viables et comprenant, éventuellement, un support pour les cardiomyocytes.
Advanced Research And Technology Institute Inc.
Indiana University Research And Technology Corporation
Smart & Biggar
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