Multispecific antigenic proteins

Details Multispecific antigenic proteins Multispecific antigenic proteins

C - Chemistry, Metallurgy

12

N

167/129, 195/1.2

C12N 15/09 (2006.01) A61K 39/385 (2006.01) C07K 14/08 (2006.01) C07K 14/105 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1340776

A novel conjugated protein produced by recombinant DNA techniques comprises a low molecular weight carrier protein portion that is normally self-aggregating to an immunogenic higher molecular weight proteinaceous material and a hapten portion wich is a peptide fraction that contains an epitope for an antigen for a pathogenic disease attached to the low molecular weight carrier portion. On aggregation of the self-aggregating protein, the hapten is on the surface of the viral particle, allowing for recognition of the hapten by the immune system. Upon introduction in vivo, the viral protein produces antibodies to both the self-aggregating protein and the hapten. A plurality of the conjugated proteins having different haptens can be combined into a viral protein to provide multi specific vaccines conferring immunity to a variety of pathogenic agents.

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