C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2542239
The present invention provides a cytotoxically active CD3 specific binding construct comprising a first domain specifically binding to human CD3 and an Ig-derived second binding domain. Furthermore, a nucleic acid sequence encoding a CD3 specific binding construct of the invention is provided. Further aspects of the invention are vectors and host cells comprising said nucleic acid sequence, a process for the production of the construct of the invention and composition comprising said construct. The invention also provides the use of said constructs for the preparation of pharmaceutical compositions for the treatment of particular diseases, a method for the treatment of particular diseases and a kit comprising the binding construct of the invention.
L'invention concerne une construction de liaison spécifique au CD3, à effet cytotoxique, comprenant un premier domaine se liant spécifiquement au CD3 humain et un deuxième domaine de liaison dérivé de Ig. L'invention concerne en outre une séquence d'acides nucléiques codant une construction de liaison spécifique au CD3. D'autres aspects de l'invention concernent des vecteurs et des cellules hôtes comprenant ladite séquence d'acides nucléiques, un procédé pour produire la construction de l'invention, ainsi qu'une composition comprenant ladite construction. L'invention concerne également l'utilisation desdites constructions pour la préparation de compositions pharmaceutiques servant au traitement de maladies particulières, un procédé pour le traitement de maladies particulières et un kit comprenant la construction de liaison de l'invention.
Baeuerle Patrick
Carr Francis J.
Hamilton Anita A.
Hofmeister Robert
Itin Christian
Goudreau Gage Dubuc
Micromet Ag
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