Multistage delivery of active agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 41/00 (2006.01) A61K 47/02 (2006.01) A61K 47/04 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2664919

Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.

La présente invention concerne des véhicules d'administration à étapes multiples qui incluent une particule de première étape et une particule de seconde étape. La particule de première étape correspond à une microparticule ou une nanoparticule qui contient la particule de seconde étape. La particule de seconde étape inclut un agent actif, tel qu'un agent thérapeutique ou un agent d'imagerie. Le véhicule d'administration à étapes multiples permet de vaincre ou d'éviter de manière séquentielle les barrières biologiques. Le véhicule d'administration à étapes multiples est administré sous la forme d'une composition qui contient une pluralité des véhicules. L'invention concerne également des procédés de fabrication des véhicules d'administration à étapes multiples.

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