Multistage electromagnetic separator for purifying cells,...

G - Physics – 01 – N

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Details

IPC codes

G01N 1/34 (2006.01) A01N 1/02 (2006.01) B01D 11/04 (2006.01) B01D 17/12 (2006.01) B01D 33/00 (2006.01) B01D 35/06 (2006.01) B01J 19/08 (2006.01) B03C 1/00 (2006.01) B03C 1/12 (2006.01) B03C 1/14 (2006.01) B03C 1/253 (2006.01) C07K 1/24 (2006.01) C12Q 1/70 (2006.01) G01N 35/00 (2006.01)

Type

Patent

Patent number

CA 2366543

Description

Innovative method for quantitatively separating cells, proteins, or other particles, comprising multistage electromagnetically assisted separation technology including a series of dipole, quadrupole or ring magnets (40, 44), stacked along the upper cylindrical cavity of the MAGSEP (10) two-plate device for activating in sequence, lowest first, to accelerate (in the sense of a magnetic induction accelerator as used in particle physics) particles upward until they reach an unstable point as defined by Earnshaw's therorem, at which time the first field is switched off and the second switched on to continue the upward capture process without sticking the particles to the wall by magnetapheresis.

L'invention concerne une méthode innovatrice servant à séparer quantitativement des cellules, des protéines, ou d'autres particules, et dans laquelle on utilise une technologie de séparation multiphase assistée par électromagnétisme, comprenant une série d'aimants dipôles, quadrupôles ou en anneau (40, 44), situés le long de la cavité cylindrique supérieure du dispositif à double plaque de séparation assistée par magnétisme (MAGSEP) (10) servant à activer en séquence les particules, en commençant par la plus basse, afin de les faire accélérer (tel un accélerateur à induction magnétique comme celui utilisé en physique des particules) vers le haut jusqu'à ce qu'elles atteignent un point instable comme celui défini par le théorème de Earnshaw. A ce moment-là, le premier champ est désactivé et le second activé afin de continuer le processus de capture ascendant sans coller les particules à la paroi par magnétophorèse.

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