A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/33 (2006.01) A61K 31/435 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) C07B 61/00 (2006.01) C07C 215/60 (2006.01) C07C 217/08 (2006.01) C07C 323/62 (2006.01) C07D 211/42 (2006.01) C07D 211/56 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 263/32 (2006.01) C07D 263/34 (2006.01) C07D 265/32 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14
Patent
CA 2321170
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the D1 receptors, preferably, agonists of the D1 receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist or antagonist of the D1 receptors. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various disorders such as hypertension, angina, congestive heart failure, renal failure (including chronic and acute renal failure), impotence, psychosexual disorders, Parkinson's disease and the like.
La présente invention concerne des composés à liaisons multiples qui sont des agonistes, des agonistes partiels, des agonistes inverses ou des antagonistes des récepteurs D¿1?, de préférence des agonistes des récepteurs D¿1?, et qui sont impliqués dans des troubles neurologiques. Les composés à liaisons multiples de l'invention contiennent de 2 à 10 ligands rattachés par covalence à un ou plusieurs lieur. Chaque ligand est un agoniste, un agoniste partiel, un agoniste inverse ou un antagoniste des récepteurs D¿1?. Les composés à liaisons multiples de l'invention conviennent pour la prophylaxie et le traitement de divers troubles tels que l'hypertension, l'angor, l'insuffisance cardiaque globale, l'insuffisance rénale chronique ou aiguë, l'impuissance, les troubles psychosexuels, la maladie de Parkinson.
Griffin John H.
Thomas G. Roger
Yang Guang
Advanced Medicine Inc.
Torys Llp
LandOfFree
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