Multivalent and/or multispecific rankl-binding constructs

Details Multivalent and/or multispecific rankl-binding constructs Multivalent and/or multispecific rankl-binding constructs

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2753263

The invention relates to combinations of RANKL antagonists with VEGF antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VHNL domain, methods of making such constructs and uses thereof.

La présente invention concerne des combinaisons d'antagonistes du RANKL avec des antagonistes du VEGF, et fournit des constructions de liaison à l'antigène qui se lient au RANKL, comprenant un support protéique qui est lié à un ou plusieurs domaines de liaison à l'épitope, la construction de liaison à l'antigène comprenant au moins deux sites de liaison à l'antigène, dont au moins un provient d'un domaine de liaison à l'épitope et dont au moins un provient d'un domaine apparié VH/VL, des procédés pour fabriquer de telles constructions et leurs utilisations.

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