C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 14/82 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01)
Patent
CA 2331641
The invention relates to a multivalent Fv antibody construct comprising at least four variable domains which are connected to one another via peptide linkers 1, 2 and 3. The invention also relates to expression plasmids which code for such an Fv antibody construct. In addition, the invention relates to a method for producing the Fv antibody constructs and to the use thereof.
La présente invention concerne une construction d'anticorps F¿v? multivalente, comportant au moins quatre domaines variables qui sont reliés l'un à l'autre par l'intermédiaire des segments peptidiques 1, 2 et 3. L'invention concerne en outre des plasmides d'expression qui codent pour une telle construction d'anticorps F¿v?, ainsi qu'un procédé de réalisation des constructions d'anticorps F¿v? et leur utilisation.
Kipriyanov Sergej
Little Melvyn
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Recht
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