Multivalent antigen-binding proteins

Details Multivalent antigen-binding proteins Multivalent antigen-binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 1/16 (2006.01) C07K 16/44 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2122732

Methods for producing multivalent antigen-binding proteins are described. The methods include purification of compositions containing both monomeric and multivalent forms of single polypeptide chain molecules, and production of multivalent proteins from purified monomers. Production of multivalent proteins may occur by a concentration-dependent association of monomeric proteins, or by rearrangement of regions involving dissociation followed by reassociation of different regions. Bivalent proteins, including homobivalent and heterobivalent proteins, are made in the present invention. Genetic sequences coding for bivalent single- chain antigen-binding proteins are disclosed. Uses include all those appropriate for monoclonal and polyclonal antibodies and fragments thereof, including use as a bispecific antigen-binding molecule.

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